Laboratory services

List of laboratory services

Pathological models

Species and characteristics of the models:

according to the model.

Description of our service

JANVIER LABS’s pathological models allow you to recreate hypothetical and described mechanisms in human and animal disease. They were developed based on current scientific knowledge and they are subject to regular monitoring allowing them to respond to ever-changing research findings.

JANVIER LABS has developed models for the study of obesity and diabetes; DIO protocols (Diet Induced Obesity, type II diabetes), possibility of inducing type I and II diabetes by destroying pancreatic islets with streptozotocin, a protocol of arthritis by injection of Freund's adjuvant, a surgical model of renal insufficiency (5/6 nephrectomy or unilateral nephrectomy).

Other surgical models include: adrenalectomy, thyroidectomy, ovariectomy on old breeding female.

JANVIER LABS also has pristanized animals for ascites and antibody production.

Our method

To induce the development of experimental pathological models, we offer:

  • Surgery Model: jaundice model in rat, osteroporosis model in rat by ovariectomy of older females breeding
  • Substance injection Model: arthritis model by Freund adjuvant injection, model of type II diabetes by streptozotocin injection in neonate WISTAR rat
  • Diet-induced Model: induced obesity by diet, hypercholesterolemia / atherosclerosis induced by high saturated fat and cholesterol diet, hypertriglyceridemia/ insulin intolerance by high fructose / sucrose diet

Possible options

  • Catheterization of the model.
  • Blood, organs and other biological products sampled.
  • Surgical excision.
  • Integration of the model in a specific protocol.

Our added value

  • A confidentiality of data obtained.
  • Traceability of interventions.
  • A dedicated team with a contact person in charge of the protocol, a single point of contact responsible for monitoring and customer relationship, a technical team for its unfolding.
  • A control of breeding conditions and monitoring.
  • Adaptation of the protocol to the needs and objectives of the researcher.
  • Ethical review process by our IACUC (MESR No. 078).

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