Research models

List of models

C57BL/6JRj
Nomenclature: C57BL/6JRj

Type: Inbred mouse
Colour and related genotype: Black mouse, a (a/a) non agouti - MHC: Haplotype H2b
Origin: CSAL (Orleans) - 1993 (F172)
Breeding: Good breeder but quite difficult to rear (sensitive to theenvironment). Cannibalism with its pups.

Fields of research

  • Cardiovascular research: atherosclerosis
  • Development biology, ageing
  • Immunology and inflammation
  • Infections
  • Metabolism: obesity, diabetes, hyperglycemia, insulin resistance
  • Neurobiology and neuro-sensorial research
  • Oncology
  • Genetic background for transgenic animals production
  • Toxicology, hematology

Description of our model

This strain was created by C.C. LITTLE, in 1921, from Miss Abbie LATHROP’s stock. The Jackson Laboratory’s colony was divided in two sub-strains before 1937, resulting in the C57BL/6 and the C57BL/10 strains. The C57BL/6 strain was brought to The Jackson Laboratory in 1948 (C57BL/6J).

It’s a widely used strain and was the first one to have its genome sequenced. It’s not very sensitive to spontaneous tumours but allows for the expression of a wide variety of mutations, hence its frequent use as genetic background in transgenic models.

C57BL/6JRj show age-related hearing loss and are resistant to audiogenic seizures. It is sensitive to Diet-Induced Type II diabetes and atherosclerosis. C57BL/6JRj can show alopecia of uncertain etiology: it could have behavioural causes – overgrooming/barbering (JAX® Notes, 1987, Sundberg et al., 2011) – or behaviour similar to human compulsive hair pulling (Garner et al., 2004).

C57BL/6JRj are also characterized by hereditary hydrocephalus (1 to 4% incidence), imperforate vagina after 24 to 28 days), low bone density, higher rates of malocclusion, high rates of microphtalmia and ocular malformations and addiction to morphine and alcohol.

C57BL/6JRj carry a deletion in the Nnt gene (arose in the C57BL/6J prior to 1984).

C57BL/6JRj are active and relatively aggressive but easy to manipulate and have a long life expectancy (2 years).

Our added value

  • The « JANVIER LABS Genetic Policy », a specific programme, guarantees homozygosity of autosomal pairs.
  • Animals with the SPF or SOPF standards.
  • A gentling policy for docile and easy-to-handle animals.
  • Optimal stability conditions of our models during shipments, thanks to our dedicated and internal transport service.
  • A scientific support with a team of Veterinarians and PhD.

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