Research models

List of models

CBA
Nomenclature: CBA/JRj

Type: Inbred mouse
Colour and related genotype: Agouti mouse, A/A - MHC: Haplotype H2k
Origin: Zentralinstitut für Versuchstierzucht (Hannover) - 1988 (F200)
Breeding: Difficult to rear

Fields of research

  • Audition
  • General studies
  • Gerontology
  • Immunology, inflammation and autoimmune disease
  • Oncology
  • Pharmacology

Description of our model

This strain was developed by Dr STRONG in 1920 from a cross of a BAGG ALBINO female and a DBA male. It was selected for a low incidence of mammary tumours. Dr STRONG sent the CBA strain to Dr ANDERVONT in 1947, who transmitted it to The Jackson Laboratory in 1948.

It’s a general-purpose strain and it is homozygous for the retinal degeneration allele Pde6brd1.

CBA/J is used in granulomatous experimental autoimmune thyroiditis (G-EAT) studies, it is resistant to diet-induced atherosclerosis and it develops mild hearing loss in the winter of her life, mainly in higher frequencies. A high incidence of tubulointerstitial lesions in the kidney is described for this strain. Some CBA/J develop a spontaneous exocrine pancreatic insufficiency syndrome.

Our added value

  • The « JANVIER LABS Genetic Policy », a specific programme, guarantees homozygosity of autosomal pairs.
  • Animals with the SPF or SOPF standards.
  • A gentling policy for docile and easy-to-handle animals.
  • Optimal stability conditions of our models during shipments, thanks to our dedicated and internal transport service.
  • A scientific support with a team of Veterinarians and PhD.

Download the corresponding health monitoring reports

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