Research models

List of models

B6 Agouti
Nomenclature: B6(C)/Rj-A/A

Download the technical sheet

Type: Inbred mouse

Colour and related genotype: Agouti mouse, A/A

Origin: Created by JANVIER LABS in 2015, principle pair F0/N11

Breeding: Good breeder

Fields of research

Cardiovascular research: atherosclerosis
Development biology, ageing
Immunology and inflammation
Infections
Metabolism: obesity, diabetes, hyperglycemia, insulin resistance
Neurobiology and neuro-sensorial research
Oncology
Genetic background for transgenic animals production
Toxicology, hematology

Description of our model

This strain was developed by crossing a C57BL/6NRj with a BALB/cAnNRj and the B6cF1 (carrier of the Tyr^mut gene) was backcrossed over 10 generations with a C57BL/6NRj genetic background. The result: an inbred mouse with a C57BL/6NRj genetic background and agouti colouring.

The B6(C)/Rj-A/A, therefore, has an agouti fur. This strain also possesses characteristics similar to a C57BL/6NRj, but does not carry the Nnt gene mutation, unlike the C57BL/6JRj.

The B6(C)/Rj-A/A is mainly used in transgenics for the creation of blastocysts intended for the reception of genetically modified ES cells by way of microinjection on mice with a C57BL/6 genetic background.

This strain can also be used in immunology research, such as C57BL/6. It is, in this case, used in the production of embryo kits, from zygotes to blastocyst stage.

Our added value

The « JANVIER LABS Genetic Policy », a specific programme, guarantees homozygosity of autosomal pairs.
Animals with the SPF or SOPF standards.
A gentling policy for docile and easy-to-handle animals.
Optimal stability conditions of our models during shipments, thanks to our dedicated and internal transport service.
A scientific support with a team of Veterinarians and PhD.