Description of our model
This strain was developed by crossing a C57BL/6NRj with a BALB/cAnNRj and the B6cF1 (carrier of the Tyrmut gene) was backcrossed over 10 generations with a C57BL/6NRj genetic background. The result: an inbred mouse with a C57BL/6NRj genetic background and agouti colouring.
The B6(C)/Rj-A/A, therefore, has an agouti fur. This strain also possesses characteristics similar to a C57BL/6NRj, but does not carry the Nnt gene mutation, unlike the C57BL/6JRj.
The B6(C)/Rj-A/A is mainly used in transgenics for the creation of blastocysts intended for the reception of genetically modified ES cells by way of microinjection on mice with a C57BL/6 genetic background.
This strain can also be used in immunology research, such as C57BL/6. It is, in this case, used in the production of embryo kits, from zygotes to blastocyst stage.