Research models

List of models

B6 Agouti
Nomenclature: B6(C)/Rj-A/A
Download the technical sheet

Type: Inbred mouse
Colour and related genotype: Agouti mouse, A/A
Origin: Created by JANVIER LABS in 2015, principle pair F0/N11
Breeding: Good breeder

Fields of research

  • Cardiovascular research: atherosclerosis
  • Development biology, ageing
  • Immunology and inflammation
  • Infections
  • Metabolism: obesity, diabetes, hyperglycemia, insulin resistance
  • Neurobiology and neuro-sensorial research
  • Oncology
  • Genetic background for transgenic animals production
  • Toxicology, hematology

Description of our model

This strain was developed by crossing a C57BL/6NRj with a BALB/cAnNRj and the B6cF1 (carrier of the Tyrmut gene) was backcrossed over 10 generations with a C57BL/6NRj genetic background. The result: an inbred mouse with a C57BL/6NRj genetic background and agouti colouring.

The B6(C)/Rj-A/A, therefore, has an agouti fur. This strain also possesses characteristics similar to a C57BL/6NRj, but does not carry the Nnt gene mutation, unlike the C57BL/6JRj.

The B6(C)/Rj-A/A is mainly used in transgenics for the creation of blastocysts intended for the reception of genetically modified ES cells by way of microinjection on mice with a C57BL/6 genetic background.

This strain can also be used in immunology research, such as C57BL/6. It is, in this case, used in the production of embryo kits, from zygotes to blastocyst stage.

Our added value

  • The « JANVIER LABS Genetic Policy », a specific programme, guarantees homozygosity of autosomal pairs.
  • Animals with the SPF or SOPF standards.
  • A gentling policy for docile and easy-to-handle animals.
  • Optimal stability conditions of our models during shipments, thanks to our dedicated and internal transport service.
  • A scientific support with a team of Veterinarians and PhD.

Download the corresponding health monitoring reports

application/pdf Certificate A02 (84.8 kB)

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