Research models

List of models

BALB/c-nu
Nomenclature: BALB/cAnN-Foxn1nu/nu/Rj

Type: Mutant inbred mouse
Colour and related genotype: Albino mouse,A/A, Tyrc/Tyrc, Tyrp1b/Tyrp1b - MHC: Haplotype H2d
Origin: Nijmegen - 2009
Breeding: Animal easy to rear, could be aggressive by handling,Mating scheme: homozygous ♂ x heterozygous ♀(homozygous ♀ can not suckle pups).

Fields of research

  • Experimental infections
  • Immunology
  • Monoclonal antibodies: study and production
  • Oncology
  • Transplantation: xenograft and allograft

Description of our model

The first nude mouse appeared in an outbred albino mouse stock at the Ruchill Hospital, Glasgow in 1962. This mutation was transferred to the stabilized genetic background of the inbred BALB/cAnN mouse by backcrossing. The genetic background was selected by MacDowell in 1923 from a stock of outbred albino mice obtained by Bagg in 1913. They were transferred to Snell at F32.

This mutation, identified by Dr. GRIST, is an autosomal recessive one and arises in the Foxn1 (forkhead box N1) gene (chromosome 11). It causes thymic aplasia which results in immunodeficiency. This results in a lack of T cells, B cells remain. This mutation also leads to a keratinisation defect of the hair follicule and the epidermis. This results in mice with transient downy hair. When this duvet is gone, mice appear nude. There is no link between the presence of down and immunodeficiency severity.

Our added value

  • The « JANVIER LABS Genetic Policy », a specific programme, the homogeneity of the genetic background, identic to the wild types used as controls.
  • Animals with the SOPF standards.
  • A gentling policy for docile and easy-to-handle animals.
  • Optimal stability conditions of our models during shipments, thanks to our dedicated and internal transport service.
  • A scientific support with a team of Veterinarians and PhD.

Download the corresponding health monitoring reports

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