Research models

List of models

DIABETIC
Nomenclature: BKS(D)-Leprdb/JOrlRj

Type: Mutant congenic strain
Colour and related genotype: Obese black mouse: Leprdb, related genotype: a/a, Leprdb/Leprdb Non obese black mouse (control): Leprdb, Dock7m, related genotype: a/a, Leprdb/+, Dock7m/+ Non obese grey mouse (control): Dock7m, related genotype: a/a, Dock7m/Dock7m
Origin: CSAL (Orléans) - 1981 (from The Jackson Laboratory in 1974)
Breeding: Good breeder, mating scheme: heterozygous ♂ x heterozygous ♀ (the homozygous mice are steriles.)

Fields of research

  • Immunology
  • Metabolism
  • Type II diabetes (NIDDM)
  • Type II diabetes-related pathologies:
    peripheral neuropathy, myocardium pathology, obesity

Description of our model

The db mutation arose spontaneously in a colony of the inbred strain C57BL/Ks/J. This mutation was backcrossed by Coleman onto a C57/BL/6J background in order to maximize the expression of the mutant Leprdb gene. This leads to a compensatory hyperplasia of the β cells in the islets of Langerhans. This gene is located on chromosome 4. The Dock7m gene (dilution of coat colour) allows to identify WT individuals for the Lepr+ gene.

This strain is a model of Type II diabetes (NIDDM) and is used in hyperglycemia, hyperinsulinaemia, insulin resistance, obesity-related diabetes, diabetic complications. (delayed scar formation, fertility problems, peripheral neuropathy, cardiomyopathy…), and endocrine disease (defects of lipocytes, hypothalamus, pituitary gland and pancreas) studies.

Our added value

  • The « JANVIER LABS Genetic Policy », a specific programme, guarantees the homogeneity of the genetic background, identic to the wild types used as controls.
  • Animals with the SOPF standards.
  • A gentling policy for docile and easy-to-handle animals.
  • Optimal stability conditions of our models during shipments, thanks to our dedicated and internal transport service.
  • A scientific support with a team of Veterinarians and PhD.

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