List of models
Type: Mutant congenic mouse
Colour and related genotype: Albino mouse, Tyrc/Tyrc , Tyrp1b/Tyrp1b - MHC: Haplotype H2d
Origin: Institut Pasteur (Lille, France) - 2009
Breeding: Animal easy to rear, strong maternal instinct, Mating scheme: homozygous ♂ x homozygous ♀
Description of our model
The scid (Severe Combined Immunodeficiency) mutation was discovered in a colony of inbred BALB/c-Ighb (CB-17/Icr, BALB/c congenic background with Ighb-Cb allel from the C57BL/Ka strain) mice in 1980 by Dr. M.J. Bosma and his team, at the Fox Chase Cancer Center (Philadelphia, PA).
This recessive autosomal mutation impairs lymphoid differentiation. These mice are deficient in T and B cells but myelopoiesis is not affected.
On a NOD background, antigen-presenting cells’ (APC), myeloid cells’ and the NK cell functions are impaired.
Most homozygotes do not have any detectable IgM, IgG1, IgG2a, IgG2b, IgG3, or IgA.
Some NOD-prkdcscid mice can become "leaky" from the spontaneous development of functional T and B lymphocytes.
Despite their defect, CB17-SCID mice survive under SOPF conditions for up to a year and are fertile.
Our added value
The « JANVIER LABS Genetic Policy », a specific programme, the homogeneity of the genetic background, identic to the wild types used as controls.
Animals with the SOPF standards.
A gentling policy for docile and easy-to-handle animals.
Optimal stability conditions of our models during shipments, thanks to our dedicated and internal transport service.
A scientific support with a team of Veterinarians and PhD.
Download the corresponding health monitoring reports