Research models

List of models

Nomenclature: Rj:NMRI-Foxn1nu/nu

Type: Mutant outbred mouse
Colour and related genotype: Albino mouse - Tyrc/Tyrc
Origin: CSAL (Orleans, France) - 1979
Breeding: Animal easy to rear, strong maternal instinct, rapid growth, Mating scheme: homozygous ♂ x heterozygous ♀

Fields of research

  • Experimental infections
  • Immunology
  • Inflammation
  • Monoclonal antibodies: study and production
  • Oncology
  • Transplantation: xenograft and allograftVirology

Description of our model

The first nude mouse appeared in in a closed but not deliberately inbred albino stock at the Ruchill Hospital, Glasgow in 1962. Dr. RYGGARD decided to use the NMRI outbred strain as the background (better viability and fertility).

This mutation, identified by Dr. GRIST, is an autosomal recessive one and arises in the Foxn1 (forkhead box N1) gene (chromosome 11).
It causes thymic aplasia which results in immunodeficiency. This results in a lack of T cells, B cells remain.

This mutation also leads to a keratinisation defect of the hair follicule and the epidermis. This results in mice with transient downy hair. When this duvet is gone, mice appear nude.

There is no link between the presence of down and immunodeficiency severity.

Our added value

  • The « JANVIER LABS Genetic Policy », a specific programme, the homogeneity of the genetic background, identic to the wild types used as controls.
  • Animals with the SOPF standards.
  • A gentling policy for docile and easy-to-handle animals.
  • Optimal stability conditions of our models during shipments, thanks to our dedicated and internal transport service.
  • A scientific support with a team of Veterinarians and PhD.

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