Research models

List of models

SHR
Nomenclature: SHR/KyoRj

Type: Mutant rat
Colour and related genotype: Albino rat - Tyrc/Tyrc - MHC: RT1k
Origin: Centre de Recherche Delalande (France) - 1978
Breeding: Animal easy to rear

Fields of research

  • Atherosclerosis
  • Cardiomyopathy
  • Hypertension

Description of our model

In 1960, OKAMOTO detected within a stock of outbred WISTAR rats from Kyoto University a male with a spontaneous hypertension and a female with high blood pressure. He bred and selected the descendants based on the expression of this hypertension (OKAMAOTO 1969) thus giving us the SHR rat (Spontaneous Hypertensive Rat). At the same time, Wistar animals with "normal" blood pressure were selected to be used as a same-genetic-background normotensive control of the Spontaneously Hypertensive rats: the Wistar Kyoto Rat (WKY).

Due to its insulin resistance, the SHR rat is a good model studying hypertension in non-obese humans (Swislocki and Tsuzuki, 1993). This rat is hyperactive; it can be used as a model for attention-deficit hyperactivity disorder – ADHD (Sagvolden and al., 1993). It’s widely used for selecting antihypertensive drugs.

SHR rats develop a spontaneous hypertension around 7-15 weeks of age. This hypertension is polygenic in origin with at least 3 genes.

Our added value

  • The « JANVIER LABS Genetic Policy », a specific programme, guarantees the homogeneity of the genetic background, identic to the wild types used as controls.
  • Animals with the SPF or SOPF standards.
  • A gentling policy for docile and easy-to-handle animals.
  • Optimal stability conditions of our models during shipments, thanks to our dedicated and internal transport service.
  • A scientific support with a team of Veterinarians and PhD.

Download the corresponding health monitoring reports

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