List of models
Type: Mutant congenic strain
Colour and related genotype: Obese black mouse: Leprdb, related genotype: a/a, Leprdb/Leprdb
Non obese black mouse (control): Leprdb, Dock7m, related genotype: a/a, Leprdb/+, Dock7m/+
Non obese grey mouse (control): Dock7m, related genotype: a/a, Dock7m/Dock7m
Origin: CSAL (Orléans) - 1981 (from The Jackson Laboratory in 1974)
Breeding: Good breeder, mating scheme: heterozygous ♂ x heterozygous ♀ (the homozygous mice are steriles.)
Fields of research
Type II diabetes (NIDDM)
- Type II diabetes-related pathologies:
peripheral neuropathy, myocardium pathology, obesity
Description of our model
The db mutation arose spontaneously in a colony of the inbred strain C57BL/Ks/J. This mutation was backcrossed by Coleman onto a C57/BL/6J background in order to maximize the expression of the mutant Leprdb gene. This leads to a compensatory hyperplasia of the β cells in the islets of Langerhans. This gene is located on chromosome 4. The Dock7m gene (dilution of coat colour) allows to identify WT individuals for the Lepr+ gene.
This strain is a model of Type II diabetes (NIDDM) and is used in hyperglycemia, hyperinsulinaemia, insulin resistance, obesity-related diabetes, diabetic complications. (delayed scar formation, fertility problems, peripheral neuropathy, cardiomyopathy…), and endocrine disease (defects of lipocytes, hypothalamus, pituitary gland and pancreas) studies.
Our added value
The « JANVIER LABS Genetic Policy », a specific programme, guarantees the homogeneity of the genetic background, identic to the wild types used as controls.
Animals with the SOPF standards.
A gentling policy for docile and easy-to-handle animals.
Optimal stability conditions of our models during shipments, thanks to our dedicated and internal transport service.
A scientific support with a team of Veterinarians and PhD.
Download the corresponding health monitoring reports